Research/art/teacher profile of a person

I. - Basic information

I.1 - Surname

Vargová

I.2 - Name

Jana

I.3 - Degrees

RNDr., PhD.

I.4 - Year of birth

1988

I.5 - Name of the workplace

Department of Cell Biology, Institute of Biology and Ecology Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia

I.6 - Address of the workplace

Srobarova 2, 041 54 Kosice

I.7 - Position

Research assistant

I.8 - E-mail address

jana.vargova@upjs.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/26415?mode=full&do=filterForm-submit&name=Jana&surname=Vargov%C3%A1&university=711000000&faculty=711020000&sort=surname&employment_state=yes&filter=Vyh%C4%BEada%C5%A5

I.10 - Name of the study field in which a person works at the university

4.02.01 BIOLOGY

I.11 - ORCID iD

0000-0002-4066-3453

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

University of Pavol Jozef Safarik in Kosice

II.b - Year

17.9.2007 – 27.8.2010

II.c - Study field and programme

Programme: Biology; Field: Biology

II.2 - Second degree of higher education

II.a - Name of the university or institution

University of Pavol Jozef Safarik in Kosice

II.b - Year

10.9.2010 – 22.5.2012

II.c - Study field and programme

Programme: Genetics and Molecular Cytology; Study field: Biology

II.3 - Third degree of higher education

II.a - Name of the university or institution

University of Pavol Jozef Safarik in Kosice

II.b - Year

3.9.2012 – 28.3.2018

II.c - Study field and programme

Molecular Cytology; Study field: Biology

II.4 - Associate professor

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
Research assistant	Department of Cell Biology, Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia	1.7.2016 - present

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
EPIC-XS workshop: New and Advanced Proteomics Technologies	EPIC-XS, European Proteomics Consortium and University of Tartu (Estonia) and University of Cambridge	2022
ISAC LETF PRAGUE Cytometry Workshop 2019	Czech Society for Analytical Cytometry and International Society for Advancement of Cytometry (ISAC)	2019
Flow cytometer standardization	Biomedical Research Center of the Slovak Academy of Sciences with BioG a BD Biosciences.	2018
Internship and course of in vivo tumorigenic model	Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic	2016
Internship & individual course of advanced flow cytometry and sorting	Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic	2015

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Cytology (seminar series)	Biology, Biology-X, Biophysics	I.	Biology
Molecular biology (seminar series)	Biology	I.	Biology
Stem Cell Biology	Genetics and Molecular Cytology; Zoology and Animal Physiology	II.	Biology

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

V.5.a - Name of the course	V.5.b - Study programme	V.5.c - Degree	V.5.d - Field of study
Introduction to Flow Cytometry	Genetics and Molecular Cytology, Zoology and animal physiology, Botany and plant physiology, Molecular Cytology and Genetics	II., III.	Biology
Experimental techniques in Biology	Biology, Biophysics	I.	Biology
Application of flow cytometry in research	Molecular Cytology and Genetics	III.	Biology

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

103

VI.1.b - Over the last six years

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Buľková V., Vargová J., Babinčák M., Jendželovský R., Zdráhal Z., Roudnický P., Košuth J., Fedoročko P. New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells. In Biomedicine and Pharmacotherapy, 2023, 163, 114829.

Majerník M., Jendželovský R., Vargová J., Jendželovská Z., Fedoročko P. Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer. In Pharmaceutics, 2022 ;14(5):1075. doi: 10.3390/pharmaceutics14051075

Babinčák M., Jendželovský R., Košuth J., Majerník M., Vargová J., Mikulášek K., Zdráhal Z., Fedoročko P. Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp. In Cancers (Basel), 2021, 13(7).

Konkoľová E., Hudáčová M., Hamuľaková S., Jendželovský R., Vargová J., Ševc J., Fedoročko P., Kožurková M. Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines. In Molecules, 2021, 26(4):1133.

Vargová J., Mikeš J., Jendželovský J., Mikešová L., Kuchárová B., Čulka Ľ., Fedr R., Remšík J., Souček K., Kozubík A., Fedoročko P.: Hypericin affects cancer side populations via competitive inhibition of BCRP. In Biomedicine & Pharmacotherapy, 2018, 99, 511-522.

Kuchárová B., Mikeš J., Jendželovský R., Vargová J., Mikešová L., Jendželovská Z., Kovaľ J., Fedoročko P.: Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status. In Photodiagnosis and Photodynamic Therapy, 2015, 12:3, 490-503

VI.3 - The most significant research/artistic/other outputs over the last six years

Nagy Ľ., Zeleňáková A., Hrubovčák P., Barutiak M., Lisnichuk M., Bednarčík J., Vargová J., Jendželovský R., Ševc J., Vilček Š. The role of pH on the preparation of citric acid coated cobalt ferrite nanoparticles for biomedical applications. In Journal of Alloys and Compounds, 2023, 960,170833.

Hudáčová M, Hamuľaková S, Konkoľová E, Jendželovský R, Vargová J, Ševc J, Fedoročko P, Soukup O, Janočková J, Ihnatova V, Kučera T, Bzonek P, Novakova N, Jun D, Junova L, Korábečný J, Kuča K, Kožurková M. Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells. In Int J Mol Sci. 2021, 22(8):3830.

Nunhart P, Konkoľová E, Janovec L, Jendželovský R, Vargová J, Ševc J, Matejová M, Miltáková B, Fedoročko P, Kozurkova M. Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity. In Bioorg Chem., 2020, 94:103393.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Citations:

CHEN J.Y. et al. Redefine the role of D-α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance. In European Journal of Pharmaceutical Sciences, 2023, roč. 190.
PETIJOVÁ L. et al. In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi. In BMC Genomics [online] 2024, 25 (1), 1-55, art.no. 555
YURTTAS C.. et al. Fluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer—A Pilot Study. In Journal of clinical medicine, 2024, 13(8), art. no. 2422

Citations:

HU J., WEN X., SONG J. Hypericin-mediated photodynamic therapy inhibits metastasis and EMT of colorectal cancer cells by regulating RhoA–ROCK1 signaling pathway. In Photochemical & Photobiological Sciences, 2024 Jul;23(7):1361 1372. doi: 10.1007/s43630-024-00601-x.
HU J. et al. Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis. In Eur J Pharmacol. 2021 Jun 5;900:174071. doi: 10.1016/j.ejphar.2021.174071.
WANG L. et al. Shikonin enhances the antitumor effect of cabazitaxel in prostate cancer stem cells and reverses cabazitaxel resistance by inhibiting ABCG2 and ALDH3A1. In Am J Cancer Res. 2020 Nov 1;10(11):3784-3800. eCollection 2020.
ŠIMEČKOVÁ Š. et al. High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells. In Sci Rep. 2019 Apr 5;9(1):5695. doi: 10.1038/s41598-019-42131-y.
HERMAWAN A., PUTRI H. Current report of natural product development against breast cancer stem cells. In Int J Biochem Cell Biol. 2018 Nov;104:114-132. doi: 10.1016/j.biocel.2018.09.012.

Mikešová L., Mikeš J., Kovaľ J., Gyurászová K., Čulka Ľ., Vargová J., Kuchárová B., Fedoročko P.: Conjunction of glutathione level, NAD(P)H/FAD redox status and hypericin content as a potential factor affecting colon cancer cell resistance to photodynamic therapy with hypericin. Photodiagnosis and Photodynamic Therapy 10:4, 470-483, 2013

Citations:

MAZUR A. et al. Use of Hypericin in Clinical Trials of Photodynamic Therapy. In Biointerface research in applied chemistry, 2024, vol. 14(4), art. no. 96
KŘIKAVOVÁ R. et al. Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(II) and Ir(III) complexes with a 1,3,4-thiadiazole-based ligand. Dalton Trans. 2023 Sep 19;52(36):12717-12732. doi: 10.1039/d3dt01696j.
KHORSANDI K, et al. Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment. In Inflamm Regen. 2022. PMID: 36192814
SHINODA, Y. et al. Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy. In Pharmaceuticals, 2021, vol. 14, no. 3, art. no. 229.
HU, J. et al. Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis. In European Journal of Pharmacology, 2021, roč. 900, art. no. 174071.
MOHAMMED, S.G., QORONFLEH, M.W. Vegetables. In Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management : Book Series. Advances in Neurobiology, 2020, 24 , pp.225-277
NOMPUMELELO SIMELANE, N.W., KRUGER, C.A., ABRAHAMSE, H. Photodynamic diagnosis and photodynamic therapy of colorectal cancer: In vitro and in vivo. In RSC Advances, 2020, vol. 10, no. 68, pp. 41560-41576
SIMELANE, NWN et al. Photodynamic diagnosis and photodynamic therapy of colorectal cancer in vitro and in vivo. In RSC ADVANCES, 2020, 10 (68) , pp.41560-41576
SOARES, H.T. et al. Pro-oxidant and Antioxidant Effects in Photodynamic Therapy: Cells Recognise that Not All Exogenous ROS Are Alike. In ChemBioChem, 2016, vol. 17, no. 9, pp. 836-842.
VEREBOVA, V. et al. Deeper insights into the drug defense of glioma cells against hydrophobic molecules. In International Journal of Pharmaceutics, 2016, vol. 503, no. 1-2, pp. 56-67.
CORT, A. et al. Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. In Oxidative Medicine and Cellular Longevity, 2016, art.no. 4251912.

Kuchárová B., Mikeš J., Jendželovský R., Vargová J., Mikešová L., Jendželovská Z., Kovaľ J., Fedoročko P.: Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status. Photodiagnosis and Photodynamic Therapy 12:3, 490-503,2015

Citations:

AJUWON O.R. et al. Nrf2-Mediated Antioxidant Response and Drug Efflux Transporters Upregulation as Possible Mechanisms of Resistance in Photodynamic Therapy of Cancers. Onco Targets Ther. 2024 Aug 5:17:605-627. doi: 10.2147/OTT.S457749. eCollection 2024.
YUAN X. et al., Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning. In CNS Neurosci Ther. 2023 May 14. doi: 10.1111/cns.14260.
WU, J.J. et al. Hypericin: A natural anthraquinone as promising therapeutic agent. In Phytomedicine, 2023, vol 111, 154654
ABDELSALAM, A.M. et al. Surface tailored zein as a novel delivery system for hypericin: Application in photodynamic therapy. In Materials Science and Engineering C, 2021, vol. 129, art. no. 112420.
DONG, X. et al. Hypericin-mediated photodynamic therapy for the treatment of cancer: A review. In Journal of Pharmacy and Pharmacology , 2021, vol. 73, no. 4, pp. 425-436.
KHOT, M.I. et al. The role of ABCG2 in modulating responses to anti-cancer photodynamic therapy. In Photodiagnosis and Photodynamic Therapy, 2020, vol. 29, art. no. 101579.
MARINHO, M.A.G. et al. Interaction Between Near-Infrared Radiation and Temozolomide in a Glioblastoma Multiform Cell Line: A Treatment Strategy? In Cellular and Molecular Neurobiology, 2021, vol. 41, no. 1, pp. 91-104.
RAY, Sidhartha et al. ADRs, ADEs and SEDs: A bird's eye view. In SIDE EFFECTS OF DRUGS ANNUAL 41: A WORLDWIDE YEARLY SURVEY OF NEW DATA IN ADVERSE DRUG REACTIONS. Amsterdam: Elsevier, 2019. ISBN 978-0-12-817164-6, pp. XXVII-XLVIII
SUN, L., LI, Z., SHANG, H., XIN, X. Hypericin Enhances Paclitaxel-Induced B16-F10 Cell Apoptosis by Activating a Cytochrome c Release–Dependent Pathway. In Frontiers in Pharmacology, 2021, vol. 12, art. no. 652452.
VARCHOLA, J. et al. Singlet oxygen produced by quasi-continuous photo-excitation of hypericin in dimethyl-sulfoxide. In Journal of Luminescence, 2016, vol. 177, pp. 17-21.
ZHANG, Y. et al. Highly efficient green synthesis and photodynamic therapeutic study of hypericin and its derivatives. In RSC Advances, 2018, vol. 8, no. 39, pp. 21786-21792.

Citations:

DOS SANTOS, J.A. et al. Study of nitrogen heterocycles as DNA/HSA binder, topoisomerase inhibitors and toxicological safety. In International Journal of Biological Macromolecules, 2024, 254(Pt 3):127651. doi: 10.1016/j.ijbiomac.2023.127651.
MOHAREB, R. M. et al. Ionic Liquids Immobilized Synthesis of New Xanthenes Derivatives and their Antiproliferative, Molecular Docking, and Morphological Studies. In Anti-cancer agents in medicinal chemistry, 2024;24(13):990-1008.
MOHAREB, R. M. et al. Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene Derivatives and their Strategy in Ionic Liquids Immobilized Reactions. In Anti-cancer agents in Medicinal chemistry, 2024, 24(9):691-708. doi: 10.2174/0118715206262307231122104748.
EL-SHARKAWY, K. et al. New Approaches for the Synthesis N-alkylated Benzo[ b]thiophene Derivatives together with their Antiproliferative and Molecular Docking Studies. In Anticancer Agents Med Chem. 2023;23(12):1429-1446. doi: 10.2174/1871520623666230316103419.
VENUGOPAL, S. et al. DNA intercalators as anticancer agents. In Chemical Biology and Drug Design, vol. 100, no. 4, pp. 580-598
CEVIK, UA et al. Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole-1,3,4-oxadiazole derivatives as human topoisomerase types I poison. In Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, vol. 35, no. 1, pp. 1657-1673.
HAMISSA, MF et al. Total synthesis of inubosin B. In Tetrahedron Letters, 2020, vol. 61, no. 52.
LAURIA Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets. In European Journal of Medicinal Chemistry, 2021, vol. 220.
NEMR, M et al. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. In Bioorganic chemistry, 2020, vol. 105.
ZHANG, B. et al. Synthesis and Anticancer Research of N-(2-aminophenyl)benzamide Acridine Derivatives as Dual Topoisomerase I and Isoform-Selective HDAC Inhibitors. In Chemistry Select, 2020, vol. 5, no. 27, pp. 8311-8318.
8318.
KOSTINA, Valentina G. - ALEXEEVA, Inna V. - LYSENKO, Nadia A. - NEGRUTSKA, Valentina V. - DUBEY, Igor Y.. Cationic carboxamide derivatives of tricyclic heteroaromatic compounds: synthesis and preliminary evaluation of antiproliferative activity. In Ukrainica Bioorganica Acta, 2020, roč. 15, č. 1, s. 34-41.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

EPIC-XS-0000051 (p.n. 823839, The European Proteomics Infrastructure Consortium providing access) funded by the Horizon 2020 programme of the European Union: ProSiPo (Proteomics of the Side Population): Comparative proteomic analysis of side and non-side populations isolated from A549 lung carcinoma cells cultivated under normoxic and hypoxic conditions.

Co-investigator of the project VEGA 1/0003/23: Changes in the regulation of BCRP transport protein expression and activity in relation to the proangiogenic and metastatic potential of cancer cells. Principal investigator: prof. RNDr. Peter Fedoročko, CSc. 2023 – 2026

Co-investigator of the project: „Nanočastice pre riešenie diagnosticko-terapeutických problémov s COVID-19 (NANOVIR)". Operational Programme Integrated Infrastructure, project “NANOVIR”, ITMS:313011AUW7, co-funded by ERDF. 01/2021 – 06/2023; Principal investigator: doc. RNDr. Adriana Zeleňáková, PhD.

Co-investigator of the project APVV-18/0125 Novel anthraquinones from natural sources for biomedical applications, 2019 –2023. Principal inestigator: prof. RNDr. Eva Čellárová, DrSc

Co-investigator of the project: Open scientific community for modern interdisciplinary research in medicine (OPENMED, ITMS2014+: 313011V455). 11/2019 - 6/2023

Co-investigator of the project VEGA 1/0022/19:Hypoxia and polymorphism of BCRP transporter as the factors affecting hypericin accumulation and efficiency in vitro and ex ovo, 2019 – 2022. Principal investigator: prof. RNDr. Peter Fedoročko, CSc.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
New and Advanced Proteomics Technologies workshop a Annual user meeting (EPIC-XS project) in Tartu, Estonia	University of Tartu (Estonia) and University of Cambridge, funded by EPIC-XS project	26.-30. June 2022	EPIC-XS, project number 823839, funded by the Horizon 2020 programme of the European Union.
„ISAC LETF PRAGUE Cytometry Workshop 2019“	CLIP laboratories 2. LF UK a FN Motol Prague, Czech Republic	11.-14. April2019	Erazmus+
Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic	Královopolská 135, 612 65 Brno-Žabovřesky, Czech Republic	02/2016 – 05/2016	Erazmus+
Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic	Královopolská 135, 612 65 Brno-Žabovřesky, Czech Republic	01/2015 – 04/2015	KVARK

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

Educational and popularization seminars at secondary schools "Scientific workshops - oncology", 4.2 - 7.3.2024
Member of the expert jury of the Student Scientific Conference at UPJŠ in Košice, Section Genetics and Cell Biology (2019) and member of the expert jury in the Section Genetics, Cell Biology and Microbiology, 2020 and Animal physiology and cell biology (2024)
Co-organization of the professional seminar "Flow cytometry - from basics to applications; BDB - digital flow cytometry "in cooperation with BioG and BD Biosciences. Faculty of Science of Pavol Jozef Safarik University in Košice, Košice, 18-19 June 2019
Participation on the program organization for the participants of the Slovakian round of the competition YOUNG EUROPAN 2019 (expert tour in the Analytical Cytometry Laboratory), 12 June 2019
European researchers' night (festival of Science)
- Microorganisms around us and within us (2013)
- Cell under a microscope (2018)

Date of last update

2025-01-01